Inorganic Oral Presentations

New Bifunctional Chelator for Cobalt, Copper, and Rhenium

Lin, Scott Yi-Heng

• Scott Yi-Heng Lin, Eszter Boros, Chris Orvig*
• Organization: University of British Columbia
• Funding: UBC

Abstract: Radiopharmaceuticals have many applications in medical imaging, therapy, and drug development. The design of these agents often involves coordination chemistry of a radioactive metal core with a ligand system that determines the stability and destination of these compounds in vivo. Bifunctional chelators (BFC), which can serve as a linker between the radioisotope and the targeting vector, have gained widespread interest as they provide an attractive design in creating target-specific radiopharmaceuticals. Cobalt, copper, and rhenium all have radioisotopes of favourable nuclear properties to be used in nuclear medicine, but no universal BFC has been developed. Here, we report the synthesis of a potential BFC that could be suitable for the three metal ions of interest. Conjugation with a biomolecule was performed, and preliminary study of coordination chemistry has shown promising results. The result of this project will provide a candidate for the development of new target-specific radiopharmaceutical agent.